Years due to travel back to his alma mater to see the renaissance and Professor Hu Sanjue, 73-year-old teacher dressed in Professor Hu, General military uniform, the spirit of strong build. Less happy to meet students and teachers. Glad to hear that Professor Hu and Li Yunqing, Chen Jun, the 2009 National Science and Technology Progress first prize, accept the award personally from President Hu Jintao, sincerely happy. talking about 26 years ago, the first prize and I were involved in the study In 1984 I was particularly pleased with the Fourth Military Medical University as a student to participate in the Professor Hu Sanjue the research team. was the world's micro-computer has just come out soon, and I'm interested in micro-computer that he developed a single board micro-electrical pulse frequency counting system. The system records the pain of damaged neurons injury data. It The Professor Hu in the United Kingdom in 1989 and the related papers published in the journal Pain. The text of my work made specifically thank. The study advanced the theory of the world, the difficulty of pain, but also explains the slow pain of the cross grateful parasympathetic dominance of the mystery. and become a pain in the basic theory of the textbook into the material. recall the work of these years was professor of the year with rigorous training inseparable. more experienced master of the Qing Su. but also for the work they can finally be able to get national honor be happy.
reproduced: remember leading model of neuropathic pain of the Department of Defense Web site]
According to Ministry of Defence website reported:
inscription
2010 after a New Year's Day morning, with the Technology Building in the Fourth Military Medical University, Li Yunqing office, Chen Jun Hu San-Jue and a few by the army and the local surrounded by reporters. Military Department Central Television reporter first asked: you 3 common to declare a Award, the subject sounds too esoteric, you can not use the most concise language, will this give us summarize the results of scientific research, easy to grasp the audience to understand.
facing camera lens, Professor Hu Sanjue answer after a little thought: Pain is a human disease, through decades of research and exploration, our original model of pain, pain caused by the initial exploration of the mechanism, proposed ideas and methods to treat pain, that's all.
not his thing ah that's so simple!
one, he is like a patient's farmers, a seed buried for decades, constantly watering or fertilizing
Professor Hu Sanjue (middle) led the students to research the Study of Pain. [ ,Source: Department of Defense Web site]
at the Fourth Military Medical University, Professor Hu Sanjue is a well-known figure, his pain research, access to national scientific and technological progress award; and singing well, is to teach the choir leader.
Hu San-Jue Jiangxi Xiushui who, though already over seventies, but hale and hearty. people who know him say he is a professor of thought, a man full of wisdom. The reason is that, no matter how esoteric science, he can with the most user-friendly words to make it clear, the students likes to hear his lecture; he engaged in research for several decades, there are striking every few years on discoveries and breakthroughs. Of course the most important is Hu San-Jue has talent and engage in scientific research and all different feeling.
the late 50s of last century, the rise of the acupuncture research boom the country was the biggest problem encountered is that the traditional academic finds acupuncture analgesia.
What is pain? is a feeling . Some pain is severe, and some pain is chronic, and some pain, agony, especially by the war trauma pain. People feel pain tolerance varies, and even the same person, due to time and place, etc. different factors, the perception of pain are not the same. International Society for the Study of Pain Pain is defined as: whether the pain, the subject tapped heavily sinking, San-Jue Hu young at heart. He knew that truth and error, but one step away, to convince those who hold negative views of the people, to be a scientific way of truth and error, to open a clear distinction drawn between the boundaries, to find a convincing scientific evidence.
decades later, Hu San-Jue pleased smile that the experiment is not complicated, the harvest is purely accidental. They will rabbit fixed shelf in the laboratory bench, allowing only the head up and down the rabbit activity, but not side to side, and then the electrode into the rabbit's nostrils, and pass on the AC. on the electrode stimulation, the rabbit down in pain when swinging, and then the rabbits one by one swing of the magnitude and frequency of record can be used to form a basis for comparative analysis curve. Then, the silver needles into acupuncture points related to the rabbit, and then given to electrical stimulation, rabbits significantly decreased the pain response, showing current stimulation is not sensitive, indicators recorded significant relief curve. In order to rule out accidental harvest of inaccuracy, they have taken the trouble to do a number of repeated experiments, resulting in a striking consistency in the heart of San-Jue Hu concluded with a local analgesic effect of acupuncture .
few months later, the paper published. Fan honor of Hu San-Jue, Wang Fuzhou paper, This was strictly research, was recognized as the principle of the earliest literature of acupuncture anesthesia. acupuncture analgesia experiment is successful, quantitative detection of animals to create a new method of pain response to compelling scientific evidence shows that the Chinese Acupuncture analgesic effect of health care.
Hu San-Jue so famous. This year, he was only 21 years old. acupuncture analgesia success of the experiment, the Wu San-Jue and forged a life of pain research edge.
a sunny morning, as usual, San-Jue Hu, one into the laboratory, experimental pain in rabbits do, trying to prove the mechanism of acupuncture analgesia. a long period of operation, so he was very tired, take the scalpel in the hands of an extremely heavy he tried to remove a part of the bone tissue, accidentally missed, sharp tip pierce the rabbit spinal cord. He had to be placed on the side of the rabbit, ferret out from the iron net and then a rabbit to experiment. After about two hours, it would only be damaged rabbit spinal cord, pain during urination hissing sound issued. HU San-Jue was screaming rabbit spines a bit strange, and caught his awareness of scientific discoveries .
hall to the success of scientific research, and sometimes a fleeting like lightning, and sometimes errors can be beautiful deception, may sometimes fall into the trap covered with flower clusters, sometimes slow and that a momentary success of the meteor pass. HU San-Jue quickly put down the experiment, tracks the sound to the front of the rabbit, reached down and gently touched its hind legs, did not think the rabbit screamed even more powerful. HU San-Jue think this is the normal spinal cord injury, there should be feeling the symptoms diminish or disappear completely the opposite. HU San-Jue acutely aware that this is not a coincidence.
Hu San-Jue's judgments are correct, he immediately to capture this fleeting shiny. After numerous repeated experiments, and finally identified the traditional theory the discovery of subversive.
1971 summer, held in Shanghai on the National Conference of acupuncture anesthesia, HU San-Jue were shocked behalf of the Fourth Military Medical University four academic report - the analgesic effect of morphine can be cut down due to the disappearance of projection neurons, a judge, a ground-breaking.
morphine internationally renowned experts, the Chinese academician look Zou Gang Hu San-Jue dignified manner: Field experiment? young people, no small matter ah! After the physical aspect of the pain response following not only not disappeared, but more sensitive to acupuncture analgesia disappear, increasing doses of morphine anesthesia, the same time seems frozen in hh does not work, experiment like a magic. < br> 1976 years, Hu San-Jue and others in experts, was the main 席巴斯波恩 American Pain Society, bodies confirmed.
the road in the pain of Science, HU San-Jue has not forgotten that research for war service, for those who sacrifice their lives for the country's wounded comrades services. war injuries heal after the pain is known as burning pain, which the same kind of pain like being grilled, the extent of their suffering is far greater than before the wound healed, and some people can not stand the pain due to prefer suicide. The aftermath of the war, close attention by governments, they did not get a valid treatment approach.
the face of this global problem, HU San-Jue was an unprecedented heavy negative pressure in the shoulder. from the 80's of last century, Hu San-Jue principle of in-depth exploration on the basis of acupuncture analgesia, began to devote themselves burning mechanisms of pain research hh
That was a month out Delicate evening, Hu San-Jue mice in an experiment to observe radio waves recorded neural response to pain, he changed the homeopathic thinking, no rules on the spontaneous wave reactions were carefully observed and compared. He finally found the big secret, even sympathetic to the excitatory effect of pathological pain, the international authority of the sympathetic nerve had no effect on pain receptors in the argument was rejected by his new discovery.
as dream, he fighting for a whole 30 years. He walked slow and steady, like a patient's farmers, a seed buried for decades, constantly watering or fertilizing, convinced and finally break ground and see the buds of hope out.
1989, his papers the first time in the world with a sympathetic excitatory effect on pain receptors, and in the international magazine concentration, physical injury and no pain sensation phenomenon.
pain research experience in the wind like the wind, no specific shape and form, there is no standard for measurement and determination to carry out research necessary to establish animal models of pain.
Hu San-Jue know, he relies entirely on the power of one person may not want to arrive to board the peak of his last. He started and co-operation of young people.
in Li Yunqing, Chen Jun and Hu completed three of common sense model under study in pain mechanisms and treatment of an original model is Hu San-Jue and his assistant Xing Junling done jointly. rely on pain model, Hu San-Jue found with the analgesic effects of descending inhibitory and sympathetic, and its related papers published in 1998 at the world famous the low back pain caused by foraminal stenosis and other diseases. The original model in China, the U.S. National Laboratory at Yale University and other applications, commonly known as CCD model. international scholars cited more than 130 times, led to his pride, in 2009, of Hu San-Jue and his research team, well-known international journals in a row on the dozens of high-quality paper, causing great concern in domestic and foreign counterparts, by the National Natural Science Foundation support, has made a series of new discoveries and breakthroughs, Science and Technology of the State and laid a solid foundation for the first prize.
Second, in the silence of the night, the world's door closed hh Once research kingdom, he would cease to exist even their own, only a long list of unanswered Data
Professor Li Yunqing (left) led the students in the Study of Pain. [Image source: Department of Defense Web site]
Li Yunqing about 1.7 meters tall, the country has a pair of font face long eyes, eyes sharp . In the Fourth Military Medical University, he is recognized as talented, his 30-year-old study abroad, year and a half to get a doctorate in advance; exceptional 33-year-old was promoted to professor; 35 years as a student representative of the Second Battalion advanced in the People's Assembly Church for the deeds, professor, Ph.D., director of the national key disciplines, the National Science Fund for Distinguished Young winner rolled into one of his endless admiration for Peking University Tsinghua University students; he was 39 years old as for the three professors, and was elected national president of the Academy of Chinese Anatomy will hh
1979, the Li Yunqing with outstanding achievements in clinical medicine was admitted to the Fourth Military Medical University, began his life with the four great doctors fate. University During the 18-year-old Li Yunqing absorb water like a sponge, like hungry to learn, to seize the seat in the library he was a frequent visitor. Li Yunqing where the Second Battalion of the students, is a rounded mass, heroes Zhang, fall into the pits to save The farmer and the sacrifice of the Central Military Commission awarded the ; honorary title. these side effects and the typical stories, including Li Yunqing inspired generations of students, including.
1984 年 Li Yunqing admitted graduate students to continue in the four major human anatomy health professional degree, under the tutelage of renowned neuroanatomy Professor Wu Shi international experts, and master of human anatomy by Professor Li Jishuo of cultivation.
summer and winter, several rounds of the Spring and Autumn, Li Yunqing completed in four MEDICAL Shuoboliandu studies, received his Ph.D. in 1991 financial assistance to the prestigious Kyoto University, Japan International studies. With 12 years of rich heritage, and he only completed one and a half ahead of time to his doctoral thesis, and included in the SCI published in international professional journals 12 papers. At the time, with such short Ph.D., Kyoto University School of Medicine in the history of only 3 years, Li Yunqing is the only Chinese people.
emerging Li Yunqing been hailed as Japan's Anatomy people. April period will be returned to, but his body has not fully recovered, the two sides instructors and students tried to persuade him to stay in Japan, treatment, until complete recovery.
a clear sky day, he leaned crutches, and walked the wound has not healed legs, a lame step, firmly boarded the return flight.
own life, although I am physically injured, but not affect life. I can not do unworthy of his alma mater, unworthy of the home crowd something unworthy of his comrades. the expense 1,020,000 yen to buy all kinds of advanced equipment.
Li Yunqing threw himself into , GLUTAMATE TRANSPORTERS, Professor Shi hands of the international arms of the older generation, took over due to pain caused by nerve injury neuropathic pain mm explore the historic mission.
2004 the World Health Organization (WHO), International Pain Society (IASP) appeal to the world: Chronic pain is a serious health problem, which itself is disease. and October 11 each year as There are three main problems: lack of ideal animal model, did not clarify the mechanism of pain, lack of effective treatment.
Li Yunqing research direction will focus on information transmission and control mechanism of pain in the study. He said that the study of pain purpose is to clarify the mechanism of drug development to guide treatment. according to the site of pain can be classified as somatic pain and visceral pain. So far, people place on physical pain, pain information transmission means have been more in-depth understanding. but Other features of the human body, like the existence of pain in the body but also regulate the transfer of information systems, to clarify the composition of the system and to mobilize their role is to start the body's own potential, to achieve analgesia purpose of a shortcut. So, Li Yunqing brain led team has been working with the central analgesic effect of endogenous descending inhibitory system research; through the establishment of the bladder, rectum, pelvic organs, represented by a visceral pain model to study the pelvic visceral pain transmission path information; by seeking to pass message body and the visceral nerve fibers in the common end position to observe the interaction between the two; the positive results of basic research, applied to guide clinical treatment of descending inhibitory system through the composition of the nucleus or descending tract of nerve fibers side next to the implanted micro-electronic chips and other methods to stimulate, through the remote control to stimulate the activation of descending inhibitory system analgesic purposes.
After 25 years of efforts, Li Yunqing team had finally achieved a key outcome of their study confirmed descending inhibitory system, the main parts of its origin and termination of neurotransmitter type, the system completed the loop in the morphology of mesolimbic analgesia confirmed. for the first time using modern scientific methods for the treasure trove of traditional medicine in the country, governance role.
research team to create the results were included in the SCI published in international journals Pain of a series of 108 papers, of which the team led by Li Yunqing number of papers accounted for 60, a declaration of the model under study in pain mechanisms and treatment of Silent night, the world's door shut, no matter what kind of bothering and lively,UGG boots, and every time he behind you. Once the research into the kingdom, he would cease to exist even their own, there is only experimental study and a long string of data to be solved. holidays to work quietly in the department his greatest enjoyment, he always smiled and said: differences are often outside in the formation of 8 hours. Professor Jun (middle), discuss the experiment with the idea of team members. [Image source: Department of Defense Web site]
named Chen Jun, the northeastern province of man, 47 years old, talking, quick thinking, act resolutely, when you face contact with him, you will find he is a strong sense of covered pedantic college professor, but also by his deep wisdom pair impressed by the eyes. He is a man full of dreams, a thoughtful people.
1986, the CHEN graduated from four doctors stayed, received medical degree. later on, he admitted to four Medical University honors nerve Anatomy of professional master's graduate students, under the tutelage of the international force and the FOS facilities In 1992 two professors, master degree CHEN, Professor, recommended by both China and Japan won the Japanese Ministry of Education Scholarship, Professor Li Jishuo personally selected for his training of path and mentor. Hong, Professor Lee earnestness of Chen Jun said: Japan's National Ministry of Education, Shiga University of Medical foreign country fee-funded doctoral students, under the tutelage of world renowned pain experts, Professor Tian Minsheng Wang. Professor Yokota, the Japanese make the best professors electrophysiological pain is one of the medical profession in Japan is well-known strict teacher, in school known for strict unreasonable. In fact, from the heart of ordinary utilitarian.
CHEN smart and practical, studious and diligent, so that the two instructors and Japan are very appreciated. Professor Li Jishuo to friends in Japan there is sponsored by the Japanese foreign exchange to the discipline, so Chen Jun was confidently Corey purchasing advanced equipment, and wrote him a letter every month, hoping his early studies abroad; Wang Wang Chen Jun Tian Zexi work to stay in Japan, the face of superior research environment, Chen Jun, did not shake the oath of Returned .
CHEN with two students, with the fastest speed, installed brought back from Japan, laboratory equipment, flew into research.
in pain research process, from model making his first start, choose what kind of models? among the thousands of settings, treatment of pain in a casual reading, he found that the ancients used to treat rheumatism bees, using the natural method With this in mind, began a bold experiment, he found bee venom, catch the two mice, one into the test rack, one into the glass case, when he will bee venom injected into mice feet, also 5,6-minute effort, began to show efficacy of bee venom, mice pain in my right foot, as the pain intensified, the mouse right foot lift up higher and higher, the more reduced the more compact body, feet is almost flat with the body, then bend to the strenuous behind the neck, mouth to pacify. CHEN stared, and he did not expect the performance of mouse and human pain are surprisingly similar. CHEN Yu surprise, and quickly take to morphine, injected into the extreme pain in mice, 7-8 minutes later, the analgesic effect of the desired result, the mouse down the pain of the right foot, feet, though still inflammation and swelling, but the body is no longer violent shaking, the experimental results so surprising, so Chen Army excited.
in later years, around the model of bee venom, he led his team conducted more than ten million times as long as 10 years of experiments, writing more than 30 SCI papers. CHEN Yu 1998 and 1999 were invited to Beijing in China Lushan and Physiology at the 20th National Congress and Academic Conference and the Second and the Third Conference of Neuroscience National Congress made a special report. He set the bees toxin-related toxicity test model and the neural mechanisms of pain in terms of occurrence of innovative research, the international had an impact .2001 Chen Jun was appointed the Ministry of Education, Department of Neurobiology, appointed him deputy director, deputy director of the Institute.
concerned about the Fourth Military Medical University, led the growth of Chen Jun, the Second Affiliated Hospital, near the new Science and Technology Building, specially set out a layer of Pain Medicine Institute, Chen Jun was appointed Director of the Institute. CHEN really opened like a set of Daqing mule, both horse Aura, another donkey endurance, and weight of cattle. Institute is he personally designed with world-class equipment, first-class talents.
as a soldier, CHEN like most is how to reduce injury due to war and to the officers and men trained to bring the pain. internationally accepted analgesics fall into two categories . First, the more than 5 days. CHEN 3 in the medical cause of great dreams, the first is to build the largest Pain Research Center, and the second is the invention of an analgesic drugs with independent intellectual property rights, third is to establish the best pain treatment of domestic Center. The first dream be realized as scheduled, the institute built in accordance with international standards, such as confocal laser scanning microscope more than ten million yuan of research equipment everything. modern laboratory made him even more powerful, he launched toward the second objective impact .1998 In November, Chen Jun, the Chinese Academy of Pain Medicine to Nanning to participate in the meeting. when he is not looking for a narcotic analgesic, and most of anesthetics have analgesic effects.
exhibition in the drug, he accidentally discovered A third pharmaceutical production from the Xuzhou , so that he never expected that the injection of The results were unexpected, is it not hard to find their own needs for many years the efficacy of analgesics? He with great enthusiasm, and began in-depth experiments. He made a special trip Xuzhou Third Pharmaceutical Factory, bought for the production of So he found a pharmaceutical factory in Xi'an, a production of 30,000. new drug came out, who do not dare eat, he would take the lead in food. At the time, he was ready to go to Denmark Zuo postdoctoral work, happened to hit the ribs, pain a lot and on the plane before he ate a few pieces of new drugs, found good results the year 1999 in August, he was held in Vienna, Austria, the Ninth World Congress on Pain results are the first to speak, caused widespread attention and experts to obtain a higher academic rating.
analgesic effects of etomidate resulted in the discovery of a new class of analgesic drugs ; the birth, spontaneous pain inhibitory effects of drugs on more than 90%, inhibition of hyperalgesia has reached more than 50%, much higher than the international standard analgesic effect, breaking the traditional analgesic morphine, pethidine addictive and have tolerated the shortcomings of .2000, obtained national patent and technology transfer, as a
1 月 11 morning, in majestic Great Hall, Li Yunqing, Hu San-Jue, CHEN three leaders in pain research to participate in the National Science and Technology Award Conference. Li Yunqing state leaders, who took over from the red foil certificate He excited eyeful tears, decades of hard to pay, and finally bear heavy fruit, it is their mission and loyalty with the party and the people to turn in a good answer sheet.
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